Michael Lampson

Associate Professor of Biology and Graduate Chair in Biology
204-I Carolyn Lynch Laboratory
lampson@sas.upenn.edu
215-746-3040
Evolution
Cell and Developmental Biology
Education: 

Ph.D., Cornell University, Weill Medical College, 2002

AB, Harvard College, 1994

Research Interests: 

Within the broad theme of cell division, our research is currently focused in three areas:

  1. Cell biological principles driving chromosome evolution through biased, or non-Mendelian, chromosome segregation in meiosis (meiotic drive).

  2. Mechanics of cell division, particularly interactions between chromosomes and spindle microtubules and regulation by mitotic kinases.

  3. Centromere inheritance through the germline.

For more information, visit the lab webpage.


Selected Publications: 

Files are available on the lab webpage. See PubMed for a complete list of publications.

Smoak EM, Stein P, Schultz RM, Lampson MA*, Black BE*. 2016. Long-term retention of CENP-A nucleosomes in mammalian oocytes underpins transgenerational inheritance of centromere identity. Current Biology 26(8):1110-6. *Shared corresponding authors.

Zaytsev AV, Segura-Peña D, Godzi M, Calderon A, Ballister ER, Stamatov R, Mayo AM, Peterson L, Black BE, Ataullakhanov FI*, Lampson MA*, Grishchuk EL*. 2016. Bistability of a coupled Aurora B kinase-phosphatase system in cell division. eLife. *Shared corresponding authors.

Chmátal, L, Yang K, Schultz RM, Lampson MA. 2015. Spatial regulation of kinetochore microtubule attachments by destabilization at spindle poles in meiosis I. Current Biology 25(14):1835-41.

Ballister ER, Ayloo S, Chenoweth DM, Lampson MA*, Holzbaur EL*. 2015. Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization. Current Biology 25(10):R407-8. *Shared corresponding authors.

Zhang M, Kothari P, Lampson MA. 2015. Spindle assembly checkpoint acquisition at the mid-blastula transition. PLoS One 10(3):e0119285. 

Ballister ER, Aonbangkhen C, Mayo AM, Lampson MA*, Chenoweth DM*. 2014. Localized light-induced protein dimerization in living cells using a photocaged dimerizer. Nature Communications 5:5475. *Shared corresponding authors.

Chmátal L, Gabrial SI, Mitsainas GP, Martínez-Vargas J, Ventura J, Searle JB, Schultz RM, Lampson MA. 2014. Centromere strength provides the cell biological basis for meiotic drive and karyotype evolution in mice. Current Biology 24(19):2295-300.

Zhang M, Kothari P, Mullins MC, Lampson MA. 2014. Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition. Cell Cycle 13(24):3828-38. 

Ballister ER, Riegman M, Lampson MA. 2014. Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint. Journal of Cell Biology 204(6):901-8.

Davydenko O, Schultz RM, Lampson MA. 2013. Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I. Journal of Cell Biology 202(2):221-9.

Liu D, Davydenko O, Lampson MA. 2012. Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. Journal of Cell Biology 198(4):491-9.

Schindler K, Davydenko O, Fram B, Lampson MA*, Schultz RM*. 2012. Maternally-recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte  maturation and early development. Proceedings of the National Academy of Sciences 109(33):E2215-22 (Cover). *Shared corresponding authors.

Chiang T, Schultz R, Lampson MA. 2012. Meiotic Origins of Maternal Age-Related Aneuploidy. Biology of Reproduction 86(1):1-7.

Wang E, Ballister E, Lampson MA. 2011. Aurora B dynamics at centromeres creates a diffusion-based phosphorylation gradient. Journal of Cell Biology 194(4):539-549 (Cover).

Salimian KJ, Ballister ER, Smoak EM, Wood S, Panchenko T, Lampson MA*, Black BE*. 2011. Feedback Control in Sensing Chromosome Biorientation by the Aurora B Kinase. Current Biology 21(13):1158-65. *Shared corresponding authors.

Lampson MA, Cheeseman IM. 2011. Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends in Cell Biology 21(3):133-40.

Chiang T, Schultz RM, Lampson MA. 2011. Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes. Biology of Reproduction 85(6):1279-83.

Chiang T, Duncan FE, Schindler K, Schultz RM, Lampson MA. 2010. Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes. Current Biology 20(17):1522-8.

Liu D, Vleugel M, Backer CB, Hori T, Fukagawa T, Cheeseman IM, Lampson MA. 2010. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. Journal of Cell Biology 188(6):809-20 (Cover).

Duncan FE, Chiang T, Schultz RM, Lampson MA. 2009. Evidence that a defective spindle assembly checkpoint is not the primary cause of maternal age-associated aneuploidy in Mouse eggs. Biology of Reproduction 81(4):768-76.

Liu D, Vader G, Vromans MJ, Lampson MA*, Lens SM. 2009. Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates. Science323:1350-3. *Corresponding author.

Courses Taught: 

BIOL 121 (Introductory Biology - Molecular Biology of Life)

BIOL 486 / CAMB 486 (Chromosomes and the Cell Cycle)

BIOL 700 (Advanced Topics in Current Biology Research)

Searle Scholar Award        

Other Affiliations: 

Secondary Faculty, Department of Cell and Developmental Biology

Cell and Molecular Biology (CAMB) Graduate Group

Biochemistry and Molecular Biophysics (BMB) Graduate Group

American Society for Cell Biology (ASCB)

Society for the Study of Reproduction (SSR)