Ph.D., Cornell University, Weill Medical College, 2002
AB, Harvard College, 1994
Within the broad theme of cell division, our research is currently focused in three areas:
- Cell biological principles driving chromosome evolution through biased, or non-Mendelian, chromosome segregation in meiosis (meiotic drive).
- Mechanics of cell division, particularly interactions between chromosomes and spindle microtubules and regulation by mitotic kinases.
- Centromere inheritance through the germline.
For more information, visit the lab webpage.
Smoak EM, Stein P, Schultz RM, Lampson MA*, Black BE*. 2016. Long-term retention of CENP-A nucleosomes in mammalian oocytes underpins transgenerational inheritance of centromere identity. Current Biology 26(8):1110-6. *Shared corresponding authors.
Zaytsev AV, Segura-Peña D, Godzi M, Calderon A, Ballister ER, Stamatov R, Mayo AM, Peterson L, Black BE, Ataullakhanov FI*, Lampson MA*, Grishchuk EL*. 2016. Bistability of a coupled Aurora B kinase-phosphatase system in cell division. eLife. *Shared corresponding authors.
Chmátal, L, Yang K, Schultz RM, Lampson MA. 2015. Spatial regulation of kinetochore microtubule attachments by destabilization at spindle poles in meiosis I. Current Biology 25(14):1835-41.
Ballister ER, Ayloo S, Chenoweth DM, Lampson MA*, Holzbaur EL*. 2015. Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization. Current Biology 25(10):R407-8. *Shared corresponding authors.
Zhang M, Kothari P, Lampson MA. 2015. Spindle assembly checkpoint acquisition at the mid-blastula transition. PLoS One 10(3):e0119285.
Ballister ER, Aonbangkhen C, Mayo AM, Lampson MA*, Chenoweth DM*. 2014. Localized light-induced protein dimerization in living cells using a photocaged dimerizer. Nature Communications 5:5475. *Shared corresponding authors.
Chmátal L, Gabrial SI, Mitsainas GP, Martínez-Vargas J, Ventura J, Searle JB, Schultz RM, Lampson MA. 2014. Centromere strength provides the cell biological basis for meiotic drive and karyotype evolution in mice. Current Biology 24(19):2295-300.
Zhang M, Kothari P, Mullins MC, Lampson MA. 2014. Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition. Cell Cycle 13(24):3828-38.
Ballister ER, Riegman M, Lampson MA. 2014. Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint. Journal of Cell Biology 204(6):901-8.
Davydenko O, Schultz RM, Lampson MA. 2013. Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I. Journal of Cell Biology 202(2):221-9.
Liu D, Davydenko O, Lampson MA. 2012. Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. Journal of Cell Biology 198(4):491-9.
Schindler K, Davydenko O, Fram B, Lampson MA*, Schultz RM*. 2012. Maternally-recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development. Proceedings of the National Academy of Sciences 109(33):E2215-22 (Cover). *Shared corresponding authors.
Chiang T, Schultz R, Lampson MA. 2012. Meiotic Origins of Maternal Age-Related Aneuploidy. Biology of Reproduction 86(1):1-7.
Wang E, Ballister E, Lampson MA. 2011. Aurora B dynamics at centromeres creates a diffusion-based phosphorylation gradient. Journal of Cell Biology 194(4):539-549 (Cover).
Salimian KJ, Ballister ER, Smoak EM, Wood S, Panchenko T, Lampson MA*, Black BE*. 2011. Feedback Control in Sensing Chromosome Biorientation by the Aurora B Kinase. Current Biology 21(13):1158-65. *Shared corresponding authors.
Lampson MA, Cheeseman IM. 2011. Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends in Cell Biology 21(3):133-40.
Chiang T, Schultz RM, Lampson MA. 2011. Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes. Biology of Reproduction 85(6):1279-83.
Chiang T, Duncan FE, Schindler K, Schultz RM, Lampson MA. 2010. Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes. Current Biology 20(17):1522-8.
Liu D, Vleugel M, Backer CB, Hori T, Fukagawa T, Cheeseman IM, Lampson MA. 2010. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. Journal of Cell Biology 188(6):809-20 (Cover).
Duncan FE, Chiang T, Schultz RM, Lampson MA. 2009. Evidence that a defective spindle assembly checkpoint is not the primary cause of maternal age-associated aneuploidy in Mouse eggs. Biology of Reproduction 81(4):768-76.
Liu D, Vader G, Vromans MJ, Lampson MA*, Lens SM. 2009. Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates. Science323:1350-3. *Corresponding author.
BIOL 121 (Introductory Biology - Molecular Biology of Life)
BIOL 486 / CAMB 486 (Chromosomes and the Cell Cycle)
BIOL 700 (Advanced Topics in Current Biology Research)