Computational modeling of ion concentration dynamics in brain tissue

Department of Mathematics Seminar Series
Marte Julie Sætra, Simula Research Laboratory
- | David Rittenhouse Laboratory A2

Over the past decades, computational neuroscientists have developed ever more sophisticated and morphologically complex neuron models. Most of these models assume that the intra- and extracellular ion concentrations remain constant over the simulated period and thus do not account for concentration-dependent effects on neuronal firing properties. Of the models that do incorporate ion concentration dynamics, few account for the electrodiffusive nature of intra- and extracellular ion transport. In this talk, I will present the first multicompartmental neuron model that accounts for ion concentration dynamics in a biophysically consistent manner [1]. I will also show how electrodiffusive modeling of neurons and glial cells can be used to explore the genesis of slow potentials in the brain [2].
[1] Sætra, M.J., Einevoll, G.T. and Halnes, G., 2020. An electrodiffusive, ion conserving Pinsky-Rinzel model with homeostatic mechanisms. PLoS Computational Biology, 16(4), p.e1007661.
[2] Sætra, M.J., Einevoll, G.T. and Halnes, G., 2021. An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain. PLoS Computational Biology, 17(7), p.e1008143.