BIOL466 - Mol Gen of Neuro Disease: Molecular Genetics of Neurological Disease

Activity
LEC
Section number integer
401
Title (text only)
Mol Gen of Neuro Disease: Molecular Genetics of Neurological Disease
Term
2019C
Subject area
BIOL
Section number only
401
Section ID
BIOL466401
Course number integer
466
Meeting times
TR 01:30 PM-03:00 PM
Meeting location
LLAB 109
Level
undergraduate
Instructors
Nancy Bonini
Description
This course will focus on the molecular basis of neurological diseases, exploring in detail key papers that cover topics including defining the disease genes, development of animal models that provide mechanistic insight, and seminal findings that reveal molecular understanding. Diseases covered will include neurological diseases of great focus today such as Alzheimer's, Fragile-X and autism, dementia, motor neuron degeneration, and microsatellite repeat expansion disorders. The course will provide a perspective from initial molecular determination through current status. Students will gain an understanding of how the molecular basis of a disease is discovered (from classical genetics to modern genomics) and how such diseases can be modeled in simple genetic systems for mechanistic insight. The course will be comprised of lectures with detailed analysis of primary literature and in-class activities. Grading will be based on class participation, exams, and written papers. Prerequisite: BIOL 251 and BIOL 421 are recommended.
Course number only
466
Cross listings
BIBB466401
Use local description
No