Using large-scale comparative -omic analyses to uncover functional elements in plant genomes.

Department of Biology Seminar Series
Dr. Andrew Nelson, Boyce Thompson Institute
- | Claire Fagin Hall Auditorium
Photo: Andrew Nelson

Hosted by Brian Gregory

Home institution: Boyce Thompson Institute

Long intergenic noncoding RNAs (lincRNAs) are a large yet enigmatic class of eukaryotic transcripts that can have a wide array of critical biological functions. The wealth of RNA-seq data available for plants provides the opportunity to implement a harmonized identification and annotation effort for lincRNAs that enables cross-species functional and genomic comparisons as well as prioritization of functional candidates. In this study we present a synopsis of recent work from our group describing the functional annotation of lincRNAs in four Brassicaceae: Arabidopsis thalianaCamelina sativa, Brassica rapa, and Eutrema salsugineum1. We then describe genetic, biochemical, and genomic efforts to begin functionally characterizing several Brassicaceae-conserved lincRNAs associated with germination and development in Arabidopsis.

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